abstract：:We have entered a new era of genomics in biomedical research with the availability of genome-wide sequences and expression data, resulting in the identification of a huge number of novel reproductive genes. The challenge we are facing today is how to determine the function of those novel and known genes and their role...

journal_title：Molecular human reproduction

authors： Lee T,Shah C,Xu EY

更新日期：2007-11-01 00:00:00

abstract：:In recent years, the impact of sperm DNA damage on fertility has become an important issue. The different technologies developed to check sperm DNA fragmentation lead to the same conclusion: DNA damage negatively impacts upon reproductive processes. Oocyte DNA repair capacity is one of the cues to understanding embryo...

journal_title：Molecular human reproduction

authors： El-Mouatassim S,Bilotto S,Russo GL,Tosti E,Menezo Y

更新日期：2007-08-01 00:00:00

abstract：:We compared latent TGF-ss binding protein-1 (LTBP-1) and fibrillin-1 (FBN-1) expression in leiomyomata and myometrium, correlated with leiomyomata size. We studied in vivo and in vitro effects of ovarian steroids using matched leiomyomata and myometrium samples from both phases of the menstrual cycle. Leiomyomata were...

journal_title：Molecular human reproduction

authors： Zhao Y,Wen Y,Polan ML,Qiao J,Chen BH

更新日期：2007-05-01 00:00:00

abstract：:Persistent organohalogen pollutants (POPs) have been suggested to be involved in changing the proportion of ejaculated Y-bearing sperm. The androgen receptor (AR), aryl hydrocarbon receptor (AHR) and aryl hydrocarbon receptor repressor (AHRR) may modulate the effect of POPs with regard to previously observed sperm Y:X...

journal_title：Molecular human reproduction

authors： Tiido T,Rignell-Hydbom A,Jönsson BA,Rylander L,Giwercman A,Giwercman YL

更新日期：2007-04-01 00:00:00

abstract：:Testis expressed gene 18 (Tex18) is a small gene with one exon of 240 bp, which is specifically expressed in male germ cells. The gene encodes for a protein of 80 amino acids with unknown domain. To investigate the function of (Tex18) gene, we generated mice with targeted disruption of the (Tex18) gene by homologous r...

journal_title：Molecular human reproduction

authors： Jaroszynski L,Dev A,Li M,Meinhardt A,de Rooij DG,Mueller C,Böhm D,Wolf S,Adham IM,Wulf G,Engel W,Nayernia K

更新日期：2007-03-01 00:00:00

abstract：:No phenotypic effect is observed in most inversion heterozygotes. However, reproductive risks may occur in the form of infertility, spontaneous abortions or chromosomally unbalanced children as a consequence of meiotic recombination between inverted and non-inverted chromosomes. An odd number of crossovers within the ...

journal_title：Molecular human reproduction

authors： Chantot-Bastaraud S,Ravel C,Berthaut I,McElreavey K,Bouchard P,Mandelbaum J,Siffroi JP

更新日期：2007-01-01 00:00:00

abstract：:Sperm capacitation is a maturation event that takes place in the female reproductive tract and is essential for fertilization. A family of phospholipid-binding proteins present in bovine seminal plasma (BSP proteins) binds the sperm membrane at ejaculation and promotes bovine sperm capacitation. Homologues of these pr...

journal_title：Molecular human reproduction

authors： Lefebvre J,Fan J,Chevalier S,Sullivan R,Carmona E,Manjunath P

更新日期：2007-01-01 00:00:00

abstract：:Idiopathic fetal growth restriction (FGR) is often associated with placental insufficiency. Previously, we isolated and characterized homeobox gene DLX4 from the placenta and provided evidence that DLX4 may regulate placental development. Here, we have investigated whether DLX4 expression levels were altered in idiopa...

journal_title：Molecular human reproduction

authors： Murthi P,Said JM,Doherty VL,Donath S,Nowell CJ,Brennecke SP,Kalionis B

更新日期：2006-12-01 00:00:00

abstract：:In male mice heterozygous for a null apolipoprotein B (apoB), allele infertility was noticed. These data led us to investigate a possible role of APOB gene polymorphism and male infertility in humans. In this case-control study, we searched for an association between the insertion/deletion (I/D) polymorphism of the AP...

journal_title：Molecular human reproduction

authors： Peterlin B,Zorn B,Volk M,Kunej T

更新日期：2006-12-01 00:00:00

abstract：:We report an improvement in the PGD test for fragile X syndrome (FXS). Recently, multiple displacement amplification (MDA) has been reported to yield large amounts of DNA from single cells. Taking into account this technique, we developed a new PGD test for FXS, enabling combined analysis of linked polymorphic markers...

journal_title：Molecular human reproduction

authors： Burlet P,Frydman N,Gigarel N,Kerbrat V,Tachdjian G,Feyereisen E,Bonnefont JP,Frydman R,Munnich A,Steffann J

更新日期：2006-10-01 00:00:00

abstract：:Placental trophoblast cells are unique endocrine cells that play vital roles during the processes of embryonic implantation and placentation. However, research into the function of human trophoblast has been largely restrained mainly due to a lack of adequate cell models. A normal placenta-origin cytotrophoblast cell ...

journal_title：Molecular human reproduction

authors： Wang YL,Qiu W,Feng HC,Li YX,Zhuang LZ,Wang Z,Liu Y,Zhou JQ,Zhang DH,Tsao GS

更新日期：2006-07-01 00:00:00

abstract：:The signals initiating the growth of primordial follicles are unknown. Growth factors such as neurotrophin 4/5 (NT-4/5) and brain-derived neurotrophic factor (BDNF) may play a role in this process. To investigate the expression of NT-4/5 and BDNF and their receptor tyrosine kinase B (TrkB) in the early developing foll...

journal_title：Molecular human reproduction

authors： Harel S,Jin S,Fisch B,Feldberg D,Krissi H,Felz C,Freimann S,Tan SL,Ao A,Abir R

更新日期：2006-06-01 00:00:00

abstract：:The Y chromosome carries several spermatogenesis genes distributed in three regions: AZFa, AZFb and AZFc. Microdeletions in these regions have been seen in 10% of sterile males with azoospermia or oligozoospermia, the most frequent of them being characterized by a complete deletion of AZFc region. A partial AZFc delet...

journal_title：Molecular human reproduction

authors： Carvalho CM,Zuccherato LW,Bastos-Rodrigues L,Santos FR,Pena SD

更新日期：2006-04-01 00:00:00

abstract：:Stress-activated protein kinase/c-Jun kinase (SAPK/JNK) is thought to be necessary for preimplantation embryonic development (Maekawa et al., 2005). However, media increases SAPK/JNK phosphorylation and these levels negatively correlate with embryonic development (Wang et al., 2005). Culture-induced stress could confu...

journal_title：Molecular human reproduction

authors： Xie Y,Puscheck EE,Rappolee DA

更新日期：2006-04-01 00:00:00

abstract：:The aim of this study was to investigate patterns of gene expression in placental samples from patients with preeclampsia (PE), persistent bilateral uterine artery notching (without PE), and normal controls. This study included placental tissue from nine women with PE, seven with uncomplicated pregnancies and five wit...

journal_title：Molecular human reproduction

authors： Hansson SR,Chen Y,Brodszki J,Chen M,Hernandez-Andrade E,Inman JM,Kozhich OA,Larsson I,Marsál K,Medstrand P,Xiang CC,Brownstein MJ

更新日期：2006-03-01 00:00:00

abstract：:Although many candidate genes have been studied in pre-eclampsia (PE), the important class of catecholamine receptors that contribute to sympathetic tone and blood pressure regulation has yet to be investigated. We therefore examined the dopamine D4 receptor (DRD4) gene. We performed a prospective family-based study i...

journal_title：Molecular human reproduction

authors： Korobochka R,Gritsenko I,Gonen R,Ebstein RP,Ohel G

更新日期：2006-02-01 00:00:00

abstract：:Microarray studies generating lists of genes with altered expression in placentas from pregnancies complicated with pre-eclampsia (PE) have so far been published in several different studies. Working under the assumption that altered gene expression in PE may be the result of altered expression of regulatory transcrip...

journal_title：Molecular human reproduction

authors： Vásárhelyi B,Cseh A,Kocsis I,Treszl A,Györffy B,Rigó J Jr

更新日期：2006-01-01 00:00:00

abstract：:Recent data demonstrated that CD4+CD25+ regulatory T (Treg) cells and an enzyme called indoleamine 2,3-dioxygenase (IDO) mediate maternal tolerance to the fetus. Interestingly, Treg cells express the CTLA-4 molecule on their surface, and B7 (CD80/86) ligation by CTLA-4 enhanced IDO activity of dendritic cells (DCs) an...

journal_title：Molecular human reproduction

authors： Miwa N,Hayakawa S,Miyazaki S,Myojo S,Sasaki Y,Sakai M,Takikawa O,Saito S

更新日期：2005-12-01 00:00:00

abstract：:FSH is a pituitary gonadotropin that along with LH plays a key role in the regulation of gonadal function. The gonadotropic hormones are composed of two subunits, the common alpha subunit and the hormone-specific beta subunit, which determines the binding to specific receptors and induction of biological response. Unl...

journal_title：Molecular human reproduction

authors： Lamminen T,Jokinen P,Jiang M,Pakarinen P,Simonsen H,Huhtaniemi I

更新日期：2005-08-01 00:00:00

abstract：:The DAZL (DAZ-like) gene is suggested to be an ancestral gene of the DAZ (deleted in azoospermia) gene on the Y chromosome, which is a strong candidate for the azoospermic factor. Recently, it has been reported that the T54A (Thr54-->Ala) polymorphism in exon 3 of the DAZL gene is associated with spermatogenic failure...

journal_title：Molecular human reproduction

authors： Yang XJ,Shinka T,Nozawa S,Yan HT,Yoshiike M,Umeno M,Sato Y,Chen G,Iwamoto T,Nakahori Y

更新日期：2005-07-01 00:00:00

abstract：:In the implantation, trophoblasts penetrate maternal decidua by secreting proteases. It has been reported that cathepsins are highly expressed in the mouse villi, and play an important role in normal embryonal growth and decidualization. In this study, we evaluated cathepsins and their endogenous inhibitors, cystatins...

journal_title：Molecular human reproduction

authors： Nakanishi T,Ozaki Y,Blomgren K,Tateyama H,Sugiura-Ogasawara M,Suzumori K

更新日期：2005-05-01 00:00:00

abstract：:Prostaglandin E2 (PGE2) plays a key role in the maintenance of human pregnancy and labour onset. PGE2 can elicit diverse actions within the uterus depending on the PGE2 receptors (EP1, EP2, EP3 and EP4) expressed. By signalling through different intracellular pathways the EP receptors may inhibit or promote smooth mus...

journal_title：Molecular human reproduction

authors： Astle S,Thornton S,Slater DM

更新日期：2005-04-01 00:00:00

abstract：:Sperm are motile cells. Thus, a significant component of the spermatogenic cycle is devoted to the formation of flagellum, a process that must be coordinated to insure proper construction. To document the temporal pattern of flagellar gene expression, we employed real-time PCR to assess changes in accumulation of a co...

journal_title：Molecular human reproduction

authors： Horowitz E,Zhang Z,Jones BH,Moss SB,Ho C,Wood JR,Wang X,Sammel MD,Strauss JF 3rd

更新日期：2005-04-01 00:00:00

abstract：:The transcription factor OCT-4 is regarded as a critical factor in controlling mammalian early embryonic development because of its role in toti-/pluripotency. In human preimplantation embryos, OCT-4 studies are limited to RNA analysis of abnormally developing embryos. This study thoroughly investigated the expression...

journal_title：Molecular human reproduction

authors： Cauffman G,Van de Velde H,Liebaers I,Van Steirteghem A

更新日期：2005-03-01 00:00:00

abstract：:Round spermatids contain high levels of extremely varied mRNAs that are synthesized either throughout early spermatogenesis or during spermiogenesis from the haploid genome. Concomitantly, with major changes in the chromatin organization, arrest of transcription occurs at midspermiogenesis. However, previous investiga...

journal_title：Molecular human reproduction

authors： Dadoune JP,Pawlak A,Alfonsi MF,Siffroi JP

更新日期：2005-02-01 00:00:00

abstract：:Psoriasin is a small calcium-binding protein first found in psoriatic lesions and also up-regulated in other inflammatory skin diseases and cancer tissues. Psoriasin is also present in the fetal epithelial cells. Its biological function is unclear, but there is both in vitro and in vivo evidence for its chemokine-like...

journal_title：Molecular human reproduction

authors： Porre S,Heinonen S,Mäntyjärvi R,Rytkönen-Nissinen M,Perola O,Rautiainen J,Virtanen T

更新日期：2005-02-01 00:00:00

abstract：:Stromal cell-derived factor-1 (SDF-1 or CXCL12) is the physiologic ligand for the chemokine receptor CXCR4. CXCR4-mediated signalling regulates cell migration and apoptosis in certain haematopoietic and neuronal cells. Using gene profiling, we determined that CXCR4 is the only chemokine receptor for which mRNA express...

journal_title：Molecular human reproduction

authors： Jaleel MA,Tsai AC,Sarkar S,Freedman PV,Rubin LP

更新日期：2004-12-01 00:00:00

abstract：:An altered inflammatory activity due to functionally relevant polymorphisms of the innate immune system may influence pathways leading to labour and, therefore, impact on the frequency of preterm birth. We examined five polymorphisms of the innate immune system in a large cohort of preterm very-low-birth-weight (VLBW,...

journal_title：Molecular human reproduction

authors： Härtel Ch,Finas D,Ahrens P,Kattner E,Schaible T,Müller D,Segerer H,Albrecht K,Möller J,Diedrich K,Göpel W,Genetic Factors in Neonatology Study Group.

更新日期：2004-12-01 00:00:00

abstract：:Embryo implantation and subsequent decidualization, trophoblast invasion and formation of a functional placenta are crucial for establishment and maintenance of pregnancy. Interleukin-11 signalling has been shown to be obligatory for adequate decidualization and trophoblast invasion in mice. Defects in IL-11 signallin...

journal_title：Molecular human reproduction

authors： von Rango U,Alfer J,Kertschanska S,Kemp B,Müller-Newen G,Heinrich PC,Beier HM,Classen-Linke I

更新日期：2004-11-01 00:00:00

abstract：:Glutathione S-transferase M1 (GSTM1), one member of the GST family, is responsible for metabolism of xenobiotics and carcinogens. Myeloperoxidase (MPO) plays an important role in the oxidation and activation of carcinogens and nitric oxide. Allelic variants of GSTM1 and MPO gene polymorphisms might impair detoxificati...

journal_title：Molecular human reproduction

authors： Hsieh YY,Chang CC,Tsai FJ,Lin CC,Chen JM,Tsai CH

更新日期：2004-10-01 00:00:00

abstract：:We have previously reported that endometrial expression of matrix metalloproteinase (MMP)-26 mRNA comes to a maximum in the early secretory phase. Since tissue inhibitor of metalloproteinase (TIMP)-4 is a potent inhibitor of MMP-26, the objective of this study was to identify the pattern of TIMP-4 mRNA expression in t...

journal_title：Molecular human reproduction

authors： Pilka R,Domanski H,Hansson S,Eriksson P,Casslén B

更新日期：2004-09-01 00:00:00

abstract：:Virtually all testicular germ cell tumours originate from a common precursor, the carcinoma in situ (CIS) cell. The precise nature of the molecular mechanisms leading to CIS remains largely unknown. We performed the first systematic analysis of gene expression in testis with CIS compared to normal testis by the differ...

journal_title：Molecular human reproduction

authors： Hoei-Hansen CE,Nielsen JE,Almstrup K,Hansen MA,Skakkebaek NE,Rajpert-DeMeyts E,Leffers H

更新日期：2004-06-01 00:00:00

abstract：:Human pregnancy represents a situation of semiallograft to maternal host. Therefore, it has been reported that tolerance to the fetal allograft represents a mechanism for maintaining a pregnancy. CD4(+)CD25(bright) regulatory T cells are known to play an important role in the development and maintenance of tolerance i...

journal_title：Molecular human reproduction

authors： Sasaki Y,Sakai M,Miyazaki S,Higuma S,Shiozaki A,Saito S

更新日期：2004-05-01 00:00:00

abstract：:Gonadotrophins exert a major effect on ovarian development and on the control of fertilization. By stimulating cells with forskolin (FK), it is possible to study which genes are activated by gonadotrophins via the cAMP cascade, and which by alternative pathways. Using RNA isolated from stimulated cells, we found that ...

journal_title：Molecular human reproduction

authors： Sasson R,Rimon E,Dantes A,Cohen T,Shinder V,Land-Bracha A,Amsterdam A

更新日期：2004-05-01 00:00:00

abstract：:The maternal aorta undergoes substantial functional and structural adaptation in pregnancy. Both aortic diameter and compliance are increased and studies of animal and human gestation indicate that these changes are initiated in early pregnancy and maintained until delivery. The mechanisms underlying aortic adaptation...

journal_title：Molecular human reproduction

authors： Kelly BA,Bond BC,Poston L

更新日期：2004-05-01 00:00:00

abstract：:Surfactant protein D (SP-D) plays a role in innate immunity against various pathogens and in vivo studies have demonstrated that SP-D also has anti-inflammatory properties. SP-D was originally demonstrated in alveolar type II cells, but recent studies have shown extrapulmonary expression of SP-D indicating a systemic ...

journal_title：Molecular human reproduction

authors： Leth-Larsen R,Floridon C,Nielsen O,Holmskov U

更新日期：2004-03-01 00:00:00

abstract：:Fluorescent in situ hybridization (FISH) studies of human preimplantation embryos have demonstrated a high proportion of chromosomal mosaicism. To investigate the different timings and nature of chromosomal mosaicism, we developed single cell multiplex fluorescent (FL)-PCR to distinguish meiotic and mitotic cell divis...

journal_title：Molecular human reproduction

authors： Katz-Jaffe MG,Trounson AO,Cram DS

更新日期：2004-02-01 00:00:00

abstract：:Maturation (M-phase) promoting factor (MPF) plays a pivotal role in oocytes during their maturation. This review concentrates on its function at three important time-points. First, its activation during meiotic progression from prophase I arrest at germinal vesicle breakdown. Second, its role during the transition fro...

journal_title：Molecular human reproduction

authors： Jones KT

更新日期：2004-01-01 00:00:00

abstract：:The influence of seminal plasma on the mRNA expression of cytokines in human endometrial epithelial and stromal cells and the cytokine production of spermatozoa were investigated in vitro. Seminal plasma and spermatozoa were collected from healthy volunteers and were screened by enzyme-linked immunosorbent assay for c...

journal_title：Molecular human reproduction

authors： Gutsche S,von Wolff M,Strowitzki T,Thaler CJ

更新日期：2003-12-01 00:00:00

abstract：:A major challenge in the comprehension of the endometrial transformations leading to the completion of each menstrual cycle in humans is in the identification of specific molecular pathways underlying these monthly turnovers. Towards this goal we compared, by the differential display technique, the relative expression...

journal_title：Molecular human reproduction

authors： Malette B,Cherry E,Lagacé M,Bernard M,Gosselin D,Hugo P,Shazand K

更新日期：2003-11-01 00:00:00